Epigenetics Regulators of Genomic Imprinting in Mammals

Zeynep Demirtaş, Fatih Bilgi, Levent Mercan


Genomic imprinting is expression of gene’s only one allele in one of homolog chromosome depending on its maternal or paternal origin. A waste number of genes which are under the imprinting effect were identified as it has a key role in mammalian growth. The first three genes which is identified as imprinted are Igf2r, Igf2 and H19 which are first discovered in mouse genome. Over a hundred genes are identified as imprinted in mammals. Most of the imprinted genes are considered as they have a key role in growth and differentiation. In this review, epigenetic regulators of imprinted genes in mammals were mentioned.


Paternal genome; Maternal genome; Imprinted genes; DNA methylation; Epigenetics

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DOI: https://doi.org/10.24925/turjaf.v4i12.1139-1142.958

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This work is licensed under Creative Commons Attribution 4.0 International License

ISSN: 2148-127X

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